This paper is designed to provide administrators with guidance for combining Microsoft Application Virtualization 5.0 (App-V 5.0) and Citrix solutions. It discusses the benefits of App-V 5.0 and Citrix, recommendations for Citrix images, App-V cache management, App-V management with Citrix, factors that impact user experience and administrative effort, and the Citrix XenApp Connector for System Center Configuration Manger 2012 SP1.